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The 2011 Nobel Prize in Physiology or Medicine on Monday was Bruce Beutler and Jules Hoffmann together "for their discoveries concerning the activation of innate immunity," and the other half to Ralph Steinman "for his discovery of dendritic cells its role in adaptive immunity. "
Following the announcement, the Nobel panel, which has no posthumous awards, said Steinman had died three days earlier.
The findings of the three Nobel prizes have revealed how innate and adaptive phases of immune response are activated and thus provided new insights into disease mechanisms. Their work has opened new avenues for the development of prevention and treatment of infections, cancer and inflammatory diseases.
Here are some details about the winners:
* Bruce Beutler
- Beutler is credited with the key finding that said one of the most fundamental questions in immunology: the question of how they felt when infections occur.
- Born in Chicago in December 1957. He received his BA from the University of California in 1976 and his Ph.D. from the University of Chicago in 1981.
- From 1981 to 1983 he continued his medical studies at the University of Texas Southwestern Medical Center at Dallas.
- Between 1983 and 1985 was a Fellow of the Rockefeller University in New York, where he became associate professor in 1985. He was also attending physician at the Rockefeller University Hospital between 1984 and 1986.
- Since 2000 has been professor of genetics and immunology at the Scripps Research Institute, La Jolla, California
* JULES HOFFMANN
- Hoffmann was born in Luxembourg in August 1941. As a student he went to France and is a French citizen.
- He graduated in Biology and Chemistry and received his Ph.D. in Biology from the University of Strasbourg, France in 1963.
- After postdoctoral training at the University of Marburg, Germany, he returned to Strasbourg, where he directed a research laboratory from 1974 to 2009. He has also served as director of the Institute of Molecular and Cellular Biology in Strasbourg, during the period 2007-2008 as president of the French National Academy of Sciences.
- As director of the laboratory, the interest of his group slowly moved to the immunity of insects. Hoffmann made his pioneering discovery in 1996, when he and his colleagues investigated how fruit flies fight infection.
* Ralph Steinman:
- Born in Canada, Steinman died on September 30, 2011, of pancreatic cancer, the awards committee and the university where he worked, said Monday.
- Steinman, 68, was Professor Henry G. Kunkel at the Rockefeller University in New York and head physician at the university hospital.
- It was a cell biologist whose research has focused on the immune system, including the human immune system in the context of various diseases.
- Steinman Early research, conducted in collaboration with the late Zanvil A. Cohn at Rockefeller, began as an attempt to understand the main target cells of the immune system.
- Steinman was born in Montreal, Canada in January 1943. He studied biology and chemistry at McGill University, qualifying in 1963. He went to study medicine and earned an MD, magna cum laude, from Harvard Medical School in 1968.
- After completing an internship and residency at Massachusetts General Hospital, he joined Rockefeller University in 1970 as a postdoctoral fellow in the Laboratory of Cellular Physiology and Immunology. He became a professor of immunology there since 1988, and was also director of the Center for Immunology and immune diseases.
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